Carcinogenesis In a life span carcinogenicity review carried out in B6C3F1 mice, methylphenidate brought about an increase in hepatocellular adenomas, and in males only, a rise in hepatoblastomas at a day-to-day dose of somewhere around sixty mg/kg/working day. This dose is somewhere around 2 periods the MRHD of 60 mg/day presented to young childre